منابع مشابه
Palladium-catalyzed N-arylation of 2-aminothiazoles.
A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
متن کاملQSAR study of anti-prion activity of 2-aminothiazoles
2-aminothiazoles is a class of compounds capable of treating life-threatening prion diseases. QSAR studies on a set of forty-seven 2-aminothiazole derivatives possessing anti-prion activity were performed using multivariate analysis, which comprised of multiple linear regression (MLR), artificial neural network (ANN) and support vector machine (SVM). The results indicated that MLR afforded reas...
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Prion diseases are fatal, untreatable neurodegenerative diseases caused by the accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrP(Sc). In an effort to identify novel inhibitors of prion formation, we utilized a high-throughput enzyme-linked immunosorbent assay (ELISA) to evaluate PrP(Sc) reduction in prion-infected neuroblastoma cell lines (ScN2a). We scree...
متن کاملSynthesis of aminothiazoles: polymer-supported approaches
Aminothiazoles and their derivatives are of immense biological importance and have been consistently synthesized via various methods. However, the synthesis of aminothiazole derivatives has some problems such as poor yields, difficult isolation procedures, use of expensive catalysts etc. Recently, polymer or solid-supported synthetic protocols have attracted the attention from the research comm...
متن کامل2-absorbing $I$-prime and 2-absorbing $I$-second submodules
Let $R$ be a commutative ring and let $I$ be an ideal of $R$. In this paper, we will introduce the notions of 2-absorbing $I$-prime and 2-absorbing $I$-second submodules of an $R$-module $M$ as a generalization of 2-absorbing and strongly 2-absorbing second submodules of $M$ and explore some basic properties of these classes of modules.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1951
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.71.12_1367